Chronic Obstructive Pulmonary Disease
Conditions
Keywords
Inspiratory muscle training, General exercise training, pulmonary rehabilitation, chronic obstructive pulmonary disease
Brief summary
Chronic Obstructive Pulmonary Disease (COPD) is a frequent disease, with increasing prevalence. Pulmonary rehabilitation through general exercise training (GET) is a corner stone of COPD care. Inspiratory muscle training (IMT) as a stand-alone therapy decreases dyspnea and improves exercise capacity. Whether IMT combined with GET adds a supplementary benefit in the rehabilitation of COPD patients is however uncertain.
Detailed description
Prospective, parallel-group, randomized controlled trial 80 COPD patients will be randomized into two groups. One group will receive general exercise training combined with inspiratory muscle training, 3 times a week, for a total of 36 sessions. The other group will receive general exercise training combined with shame inspiratory muscle training, 3 times a week, for a total of 36 sessions. We will assess the difference of improvement in exercise capacity between the 2 groups with the 6 minute walking test. We will also assess the difference of improvement in quality of life with St-George's respiratory questionnaire. Finally the difference of improvement in maximal inspiratory pressure will be determined. Patients and investigators assessing the outcomes will be blinded to group allocation. Written informed consent will be obtained from each subject. The data will be treated anonymously.
Interventions
DEVICEInspiratory muscle training with Threshold by respironics
Inspiratory muscle training 15 minutes, 3x/weeks, 36 sessions Intensity: 15% of PiMax during the first week. Then increment of 5% each session until 60% of PiMax after the first month. The PiMax will be reassessed after 12 and 24 sessions in order to readjust the 60% of PiMax.
with Threshold by respironics 15 minutes, 3x/weeks, 36 sessions Intensity: 5 centimeters of water (cmH20)
Sponsors
Hôpital Riviera-Chablais, Vaud-Valais
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
40 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* COPD demonstrated by spirometry using Gold Criteria * Patient referred by a pneumologist to the ambulatory pulmonary rehabilitation program at the Riviera-Chablais Hospital, Monthey * Patient with maximal inspiratory pressure \< 60 cmH20 * Patient older than 40 years
Exclusion criteria
* Orthopaedic or neurological troubles that could slant the 6 minute walking test
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Exercise capacity (six minute walking test) | 12 weeks | exercise capacity will be assessed by a six minute walking test |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Quality of Life (St-George's Respiratory questionnaire) | 12 weeks | Quality of Life will be assessed by St-George's Respiratory questionnaire |
| Maximal inspiratory pressure (MicroRPM by MicroMedical) | 12 weeks | Inspiratory maximal pressure will be assessed by the MicroRPM by MicroMedical |
Contacts
Primary ContactStéphanie Vaudan, BSc
Backup ContactNicolas Garin, MD
Outcome results
None listed