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Risk of Falling in Chronic Kidney Disease 5

Frailty, Cardiovascular Function and Risk of Falling in Patients Receiving Haemodialysis Treatment

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT02392299
Enrollment
93
Registered
2015-03-18
Start date
2015-09-30
Completion date
2018-08-29
Last updated
2018-08-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Stage 5 Chronic Kidney Disease

Brief summary

The purpose of this study is to explore the relative importance of the frailty and cardiovascular function as potential exercise-modifiable risk factors for falling in patients receiving haemodialysis.

Detailed description

Falls and fall-related injuries in elderly people are common worldwide, and ageing populations will further raise the burden and costs. Within the UK, falls have become a major government target, as they have been responsible for increased injuries and hospital admissions in elderly people. The fall rate amongst patients on haemodialysis (HD) is much greater than in the general population. There are many well established risk factors for falling, many of which are commonly present in patients on HD, including severe loss of muscle mass, high levels of inactivity, co-existing medical conditions and a high number of medications. Nonetheless, the main cause of health complications and death in Chronic Kidney Disease (CKD) is due to cardiovascular disease. Cardiovascular disease may result in suboptimal regulation of blood pressure and heart rate during exercise, dialysis therapy, body transfers, and general activities of daily living. Associated symptoms such as dizziness, generalised fatigue, and muscular weakness, are commonly reported and may further predispose patients on HD to balance deficits and falls. Despite the evidence of high falls rates in patients on HD and the growing number of elderly patients, falls and their associated risk factors have received little research attention. The aim of this study therefore is explore the relative importance of selected exercise-modifiable risk factors for falling amongst patients on HD.

Interventions

None listed

Sponsors

British Renal Society
CollaboratorOTHER
British Kidney Patient Association
CollaboratorUNKNOWN
Queen Margaret University
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* 18 years old * Able to write/speak fluent English * Stable dialysis

Exclusion criteria

* Unstable dialysis and medication treatment * Lower limb amputees without prothesis * Unstable cardiac condition * Suspected or known aneurysm * Clinically severe left ventricular outflow obstruction * Critical mitral stenosis * Critical proximal coronary artery stenosis * Critical cerebrovascular stenosis * Pregnancy * Severe cognitive impairment

Design outcomes

Primary

MeasureTime frame
Falls incidenceOne year

Secondary

MeasureTime frameDescription
Frailty componentsbaselinemuscle strength, balance, gait speed, body composition

Other

MeasureTime frameDescription
Cardiovascular Functionbaselineblood pressure, baroreceptor reflexes

Countries

United Kingdom

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 28, 2026