Connective Tissue Diseases, Skin Tissue Diseases
Conditions
Brief summary
The purpose of this study is to assess the effect of LEO 130852A gel 1% in maintaining skin thickness in healthy skin treated with steroid.
Interventions
Sponsors
LEO Pharma
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
SINGLE (Investigator)
Eligibility
Sex/Gender
MALE
Age
25 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy male volunteers, 25 to 50 years old inclusive * Healthy skin on volar arms with a hairless area sufficient for measurements
Exclusion criteria
* Clinical skin atrophy, telangiectasia or striae on volar arms * Presence of any skin condition or colouration that would interfere with test sites or the response or assessment * Fitzpatrick skin type IV - VI * History or current evidence of infection, eczema or other relevant skin disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Skin thickness measured by sonography and histology | 4 weeks |
Secondary
| Measure | Time frame |
|---|---|
| Clinical assessments measured by atrophy score | 4 weeks |
| Clinical assessments measured by telangiectasia score | 4 weeks |
Countries
Germany
Outcome results
None listed