Membrane Shedding During Severe Sepsis and Septic Shock: Pathophysiological and Clinical Relevance

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02391792

Enrollment

300

Registered

2015-03-18

Start date

2013-03-31

Completion date

2020-03-31

Last updated

2016-08-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Severe Sepsis and Septic Shock

Brief summary

Microparticules (MPs) result from plasma cell membrane remodeling and shedding after cell stimulation or apoptosis. MPs are know recognized as a pool of bioactive messengers with merging role in pathophysiology of immune and cardiovascular diseases. MPs have been characterized during septic shock and may contribute to dissemination of pro-inflammatory and procoagulant mediators. This a prospective observational study of circulating MPs and blood coagulation in septic shock patients admitted in medical intensive care units (ICUs) of four tertiary hospitals at baseline (D1, D2, D3, D4, D7).

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 85 Years

Healthy volunteers

Inclusion criteria

* Septic shock (patients) * Without septic shock (control) * Informed consent

Exclusion criteria

* Class IV heart failure * Child-plugh grade C cirrhosis * Cancer under active treatment * BMI\>35kg/m2 * Moribund patient * DNR decision

Design outcomes

Primary

Measure	Time frame
Change from baseline in number and type of circulating microparticles at 7 days	Baseline and 7 days
Change from baseline in blood coagulation markers at 7 days	Baseline and 7 days

Countries

France

Contacts

Primary ContactFerhat MEZIANI, MD, PhD

ferhat.meziani@chru-strasbourg.fr

Outcome results