Appendicitis
Conditions
Brief summary
The Hasselt Appendicitis Immunology and Environmental Study (HAPPIEST) aims at characterizing factors that influence the development and severity of acute appendicitis. In a cohort of 300 patients and 300 controls, environmental factors as well as genetic make-up of the innate immune system, focusing mainly on pattern recognition, will be analyzed in order to gain insight in their relative importance in the pathology of appendicitis. Furthermore, populations of micro-organisms present in the gut of patients will be characterized, and the interaction between relevant micro-organisms and the innate immune system will be analyzed.
Interventions
None listed
Sponsors
Radboud University Medical Center
Jessa Hospital
Hasselt University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
5 Years to 85 Years
Healthy volunteers
Yes
Inclusion criteria
* Acute appendicitis * Appendectomy within 7 days after onset of symptoms * Signed informed consent
Exclusion criteria
* Appendectomy 7 days or more after onset of symptoms * Participation in any clinical investigational drug study within 4 weeks of screening * Severe, life-threatening disease with a life expectancy of less than 2 months.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Genetic susceptibility | Within 2 years after inclusion of the last patient | DNA sample collected at inclusion |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Immunology composite outcome | within 4 years | ex vivo peripheral blood mononuclear cell (PBMC) stimulation experiments |
| Environmental factors | Within 6 months after inclusion of the last patient | Questionnaire filled in at inclusion |
Other
| Measure | Time frame | Description |
|---|---|---|
| Quality of life | 4-6 weeks after inclusion for appendicitis | Questionnaire at outpatient visit |
Countries
Belgium, Netherlands
Outcome results
None listed