Birth Defects, Children Development, Environmental Exposures, Other Pregnancy With Abortive Outcome
Conditions
Keywords
birth cohort study, environmental exposures, birth defects, pregnant outcomes, children development
Brief summary
The China-Anhui Birth Cohort Study (C-ABCS) was set up to examine the delayed, cumulative and interactive effects of maternal environmental exposures on birth outcomes and children's development. The C-ABCS recruited pregnant women from six major cities of Anhui province, China, between November 2008 and October 2010. A range of data (including demographic, obstetric, occupational, nutritional and psychosocial factors) were collected by both interviews and laboratory tests. In each trimester, women's blood samples were drawn, and pregnancy complications were abstracted from physician's medical records. By the end of 2011, birth outcomes/birth defects were observed/identified by clinicians within 12 months after the delivery of 11 421 singleton live births of six cities and those outcomes among the remaining 2033 live births are still being observed. In addition, 4668 children from Ma'anshan city will be further followed up during the pre-school period till they reach adolescence to obtain the data on familial environmental exposures as well as children's physical, psychological, behavioural and sexual development. The interview data and information on laboratory examinations are available on request from archives in the Anhui Provincial Key Laboratory of Population Health & Aristogenics.
Interventions
OTHERNo intervention
Sponsors
Fangbiao Tao
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
17 Years to 49 Years
Healthy volunteers
Yes
Inclusion criteria
1. Having been lived in local city at least 6 months; 2. Establishing maternal card in the hospital for the first time; 3. Gestational week ≤ 16 weeks; 4. Willing to have antenatal checkups and childbirth in the hospital where they establish maternal cards.
Exclusion criteria
1. Women who have abnormities in speaking and can not complete the survey by themselves; 2. Women with mental disorders; 3. Women who plan to leave local places.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Pregnancy outcomes and birth defects | Up to 12 months of age | By clinical diagnosis, including abortion/premature birth/prolonged pregnancy/fetal death/stillbirth/live birth, Low birthweight/macrosomia/small for gestation age/large for gestation age, Structural birth defects and functional birth defects |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Children's physical development | At ages of 1.5-3 and 4.5-6 years | Including body height/length, body weight, blood pressure, blood lipoid |
| Psychological and behavioural development | At ages of 1.5-3 and 4.5-6 years | cognition, behaviour and temperament |
| Family environmental exposure | At ages of 1.5-3 and 4.5-6 years | Eating patterns and parenting style. |
| Mental health problems | At ages of 1.5-3 & 4.5-6 years | Mental retardation, attention deficit hyperactivity, disorder, autism spectrum disorders. |
| Sexual development indicators | At ages of 9-15 years for boys, and 8-14 years for girls | Secondary sexual characters, Sexual hormones. |
Outcome results
None listed