Heart Failure
Conditions
Keywords
heart failure, cardiac sympathetic nerve block, sympathetic nervous system
Brief summary
The purpose of this study is to evaluate the effect of Cardiac Sympathetic Blockade on Mortality, re-hospitalization rate, symptoms, quality of life, exercise tolerance, cardiac structure, systolic function, electrical activities and concentration of B - type natriuretic peptide precursor in patients with Chronic Heart Failure.
Interventions
DRUGLidocaine
0.5% lidocaine 5ml epidural injection every 2 hours per day or 0.2% ropivacaine 5ml epidural injection every 4 hours per day, last for 4weeks
Sponsors
First Affiliated Hospital of Harbin Medical University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Intervention model description
Randomized controlled trial
Eligibility
Sex/Gender
ALL
Age
20 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* 20-70 years old * more than 3 months of chronic heart failure history or clinical symptoms of heart failure last for more than 3 months (including acute episode of chronic heart failure), chronic heart failure diagnostic criteria refer to 2012ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure * NYHA functional class III-IV, ejection fraction ≤45% * NT-proBNP\>400ng/L
Exclusion criteria
* first episode of acute heart failure * unrepaired valvular heart disease accompanied with Hemodynamic changes * hypertrophic cardiomyopathy, pericardial disease, congenital heart disease, severe pulmonary hypertension * Second-degree type 2 or worse sinoatrial or atrioventricular block without pacemaker therapy * right heart failure caused by various diseases, respiratory failure or right heart failure induced by chronic obstructive pulmonary disease * overt renal decompensation: serum creatinine\>2.1mg/dl(186umol/L) * severe hepatic dysfunction, transaminase or alkaline phosphatase \> 3 times the upper limit of normal * Cerebral vascular accident in three months( cerebral infarction, cerebral embolism, cerebral hemorrhage,etc) * life expectancy shorter than 6 months * patients with a previous or present history of tumour or precancerous lesions confirmed by pathological examination * Spine Deformity or skin infection at puncture site * participate in any clinical drug trials in the three months * the patients who do not sign the informed consent, unable or unwilling to comply with the requirements of the protocol or unsuitable for the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| All cause mortality | one year |
Secondary
| Measure | Time frame |
|---|---|
| Rehospitalization rate | one year |
Countries
China
Contacts
Primary ContactFengqi Liu, PhD
Outcome results
None listed