Neoplams
Conditions
Keywords
Advanced Solid Tumor
Brief summary
This is a single center pilot study testing the use of novel coil arrays with MR liver imaging. In part A of the study, up to 30 healthy volunteers will be scanned, with iterative adjustment of coil array geometry and design to optimize imaging characterstics. In Part B of the study, 40 patients with advanced solid tumors and at least one liver metastasis measuring \> 1.5 cm in diameter on standard anatomic scans will undergo MR liver imaging with the newly designed coil array, with the use of gadolinium contrast. Patients with liver tumors will have the option of undergoing a second MR liver scan during the course of subsequent systemic therapy.
Interventions
PROCEDUREMRI
Sponsors
University of California, San Francisco
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
(Part B only - Patients with advanced solid tumor): * Advanced solid tumor malignancy and the presence of at least one liver metastasis measuring \> 1.5 cm in longest diameter in axial dimension on standard anatomic imaging
Exclusion criteria
(Part B only): * Contra-indication to gadolinium contrast (e.g. chronic renal disease, prior allergic reaction) for patient studies
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Spatial Resolution | Day 1 | Adjust the coil array to optimize spatial resolution in healthy volunteers |
| Scan coverage | Day 1 | Adjust the coil array to optimize scan coverage of the liver in healthy volunteers |
| Mean contrast-to-noise ratio | Day 1 | Detectable using the coil array |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Minimum size of detectable metastatic lesion | Day 1 | Detected by MRI scan |
| Degree signal | Day 1 | Detected by gandolinium contrast in MRI scan within liver metastases |
| Time-to-peak signal | Day 1 | Detected by gandolinium contrast in MRI scan within liver metastases |
Countries
United States
Outcome results
None listed