Type 1 Diabetes
Conditions
Keywords
type 1diabetes, IFN γ, IL-2, TNF α
Brief summary
The mechanism of β cell destruction in Type 1 diabetes is not exactly known, Our hyphotesis is that interferon gamma, interleukin-2 and tumor necrotizan factor alpha have impotant roles in β cell destruction.
Detailed description
T helper (h)1 cells are known to have important roles in the destruction or/and dedifferentiation of β-cells in type 1 diabetes (T1D). Significant increase in IFN-γ-producing Th1 cells in the pancreas and in the serum levels were determined in type 1 diabetic patients at diabetes oneset. This data indicated that this proinflammatory mediator serve as a biomarker of advanced autoimmunity. We aimed to investigate the relationship between Th1 cytokines (IFN-γ, IL-2 and TNF-α) and T1D and the effect of those cytokines on β-cell function.
Interventions
None listed
Sponsors
Istanbul Medeniyet University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
Yes
Inclusion criteria
* Patients giving consent to participate the study * Patients with type 1 diabetes according to WHO definiton
Exclusion criteria
* Acute and chronic inflammatory diseases, * significant concomitant diseases which may interfere with glucose metabolism * cancers, * hemoglobinopathies, * recently received antibiotics, * drugs influencing β-cell function and * insulin sensitivity or anti-inflammatory drugs * recent history of trauma
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Roles of interferon gamma, interleukin-2, tumor necrotizan factor alpha in the pathogenesis of type 1 diabetes | 3 day |
Countries
Turkey (Türkiye)
Outcome results
None listed