Urinary Neurotrophin Levels in Healthy Children

Age and Daytime Variations in Urinary Neurotrophin Levels in Healthy Children Without Lower Urinary Tract Symptoms

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02389270

Enrollment

150

Registered

2015-03-17

Start date

2016-03-31

Completion date

2016-12-31

Last updated

2016-03-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Overactive Bladder

Keywords

Neurotrophins, Nerve Growth Factor, Brain-Derived Neurotrophic Factor, Urinary Biomarkers, Children

Brief summary

The aim of this study is to analyse urinary neurotrophin levels in healthy children. Urine samples will be collected at 3 different times of day (morning, noon, and evening) at urge sensation from all age groups of children who gained bladder control, i.e. from 3-18 years of age. Urinary levels of nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) normalised to urinary creatinine will be analysed. Age and daytime related variations will be reported for both boys and girls. These results will contribute to understanding the role of neurotrophins in the physiology of lower urinary tract and pathophysiology of idiopathic and secondary hyperactive bladder in children.

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

3 Years to 18 Years

Healthy volunteers

Yes

Inclusion criteria

* 3-18 years of age * a unremarkable clinical examination * a normal voiding pattern * a minimum of 3 micturitions per day * informed oral and written consent from the child and both parents/legal guardian

Exclusion criteria

* history of urinary tract infection * diseases of central or peripheral nerve system * anomalies of lumbosacral region * chronic diseases * operative procedures or anomalies of urinary or genital tract * lower urinary tract symptoms * constipation * hypercalcuria * urolithiasis, depression, eating disorders or cardio-metabolic diseases * prior use of anticholinergic treatment

Design outcomes

Primary

Measure	Time frame	Description
Concentration of urinary nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) normalised to urinary creatinin	Collection of urine samples and analysis will take approximately 6 months.	We will collect urine samples from healthy children without lower urinary tract symptoms and analyse urine concentrations of neurotrophins (NGF and BDNF) normalised to urinary creatinin in order to report its normal age- and daytime-related variations.

Contacts

Primary ContactSlaven Abdovic, MD, PhD

sabdovic@gmail.com+38514600132

Outcome results