Acute Coronary Syndrome
Conditions
Keywords
Positron emission tomography, Tissue background ratio, Optical coherence tomography, Thin cap fibroous atheroma, Vulnerability, Acute coronary syndrome
Brief summary
Recently, positron emission tomography(PET) using 18F-Sodium fluoride (NaF) showed promising results for detecting vulnerable plaques in some pilot studies. In this study, the investigators will evaluate the diagnostic accuracy of 18F-NaF PET for non-invasively detecting vulnerable plaque, diagnosed by optical coherence tomography (OCT).
Detailed description
It has been well known that mechanism of acute coronary syndrome is plaque rupture and occlusion of coronary artery by this plaque rupture. Until now, evaluation of vulnerable plaque have been mainly performed with invasive imaging modalities such as optical coherence tomography or intravascular ultrasound. Recently, positron emission tomography(PET) using 18F-Sodium fluoride (NaF) showed promising results for detecting vulnerable plaques in some pilot studies. In this study, we will evaluate the diagnostic accuracy of 18F-NaF PET for non-invasively detecting vulnerable plaque, diagnosed by optical coherence tomography (OCT).
Interventions
None listed
Sponsors
Seoul National University Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
20 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* 1\. Patients with angina pectoris who are scheduled to do invasive coronary angiography. * 2\. Patients who have moderate (40-70%) stenosis at proximal or mid-portion of major coronary arteries. Confirmed by coronary CT angiography. * 3\. Patients who are anticipated coronary artery disease.(Probability \> 90 %) * 4\. Acute coronary syndrome.
Exclusion criteria
* 1\. Stenosis at distal coronary or small vessel. * 2\. Patients who don't have moderate (40-70%) stenosis at proximal or mid-portion of major coronary arteries. Confirmed by invasive coronary angiography. * 3\. Inadequate quality of 18F-NaF PET-CT * 4\. Inadequate quality of Optical Coherence Tomography (OCT), IVUS, Coronary CT angiography
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Difference of tissue background ratio measured by 18F-NaF PET between Vulnerable and non-vulnerable plaque | up to 1 week | Difference of tissue background ratio measured by 18F-NaF PET between Vulnerable and non-vulnerable plaque |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Number of participants demonstrating at least 1 low-attenuation coronary atherosclerotic plaque | up to 1 week | Number of participants demonstrating at least 1 low-attenuation coronary atherosclerotic plaque |
| Cardiac death and all-cause mortality | 1 year | Between High-TBR and Low-TBR Plaque |
| Differencce of Maximum SUV value between Vulnerable and non-vulnerable plaque | up to 1 week | Tissue-to-background ratios were calculated for each participant by dividing the maximal SUV measured in aortic valves by the mean SUV of blood in inferior vena cava |
| Non-fatal target vessel myocardial infarction | 1 year | Between High-TBR and Low-TBR Plaque |
| Target vessel revascularization | 1 year | Between High-TBR and Low-TBR Plaque |
| Target vessel restenosis | 1 year | Between High-TBR and Low-TBR Plaque |
Countries
South Korea
Contacts
Primary ContactBon-Kwon Koo, MD, PhD
Backup ContactJoo Myung Lee, MD, MPH
Outcome results
None listed