A New Method for Estimating Dynamic Intrinsic PEEP

A New Method for Estimating Dynamic Positive End-expiratory Pressure. Description and Validation With PEEPi Dyn Measured With Transdiaphragmatic Pressure

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02388282

Acronym

echoPEEPi

Enrollment

Registered

2015-03-17

Start date

2015-04-30

Completion date

2015-11-30

Last updated

2015-12-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

PEEP, Intrinsic, PEEP, Occult, Respiratory Insufficiency

Keywords

dynamic intrinsic PEEP, diaphragm echography, respiratory mechanics

Brief summary

Dinamic intrinsic PEEP is

Detailed description

Dynamic intrinsic positive end-expiratory pressure (PEEPi dyn) play an important pathophysiology role in many acute respiratory pathologies. The most accurate method to quantify PEEPi dyn is to measure the rise in transdiaphragmatic pressure (Pdi) at end expiration at the point of the contraction of the inspiratory muscles until inspiratory flow starts. Such method, however, is invasive, poor comfortable and require patient active collaboration. The purpose of this study is describe a new non-invasive method for estimate PEEPi dyn and validate this method with gold-standard-one.

Interventions

DEVICEdiaphragm ecography

recording of diaphragm ecography

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Acute or chronic respiratory failure * Age \>=18 y

Exclusion criteria

* Lack of informed consent * Controindication to the placement of oesophageal and gastric catheter: esophageal varices, gastric or oesophageal bleeding in the previous 30 days, gastric or oesophageal surgery in the preceding year. * Cardiac arrest * Severe emodinamic instability (\> 1 vasoacttive drug) * Acute coronary syndrome (AMI/UA) * Inability to protect airway * Respiratory arrest * Pregnancy suspected or confirmed * Diaphragm palsy * Curarization in the preceding five hours * Mechanical ventilation in controlled mode.

Design outcomes

Primary

Measure	Time frame
Correlation and agreement between AutoPEEP recorded with the transdiaphragmatic pressure (Pdi) vs ecography measurements.	20 minutes

Secondary

Measure	Time frame
Correlation and agreement between neural inspiratory time and ecographic inspiratory time	10 minutes
Inter-rater agreement to assest method reliability	10 minutes

Countries

Italy

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026