Spontaneous Bacterial Peritonitis
Conditions
Keywords
profiles changes, microorganisms, cefotaxime, SBP, Egyptian, effective antibiotics
Brief summary
Spontaneous bacterial peritonitis (SBP) is a serious complication in cirrhotic patients, and the changes in the microbiological characteristics reported in the last years are impacting the choice of antibiotic used in the treatment. Cefotaxime has been the most extensively studied antibiotic for this infection. It is considered to be one of the first choice antibiotics because of low toxicity and excellent efficacy. Treatment of SBP by intravenous cefotaxime should be administered for a minimum 5 days. Antibiotic-resistant microorganisms have been increasingly reported especially to cefotaxime and its effect on the clinical outcome in treating SBP.
Interventions
DRUGCefotaxime
Sponsors
Dr Ahmed Ali Elbaz
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* patients with liver cirrhosis and ascites and clinical findings suspicious of ascitic fluid infection
Exclusion criteria
* Patients were excluded if they received antibiotics ten days prior to the hospital admission or there is evidence of secondary bacterial peritonitis, tuberculous peritonitis, malignant ascites or ascites due to other causes e.g. cardiac or renal diseases
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Organisms detected with their antibiotics sensitivity | 8 months |
Countries
Egypt
Outcome results
None listed