Effects of Total Knee Replacement on Early Postoperative Cognitive Function in Elderly Patients

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02387541

Acronym

POCD

Enrollment

100

Registered

2015-03-13

Start date

2012-03-31

Completion date

2014-01-31

Last updated

2016-05-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Perioperative Complications

Keywords

Postoperative cognitive dysfunction

Brief summary

To investigate the effects of total knee replacement is harmful to Postoperative cognitive dysfunction

Detailed description

Postoperative cognitive dysfunction (POCD) is reported to occur after major surgery in elderly patients. They may especially experience problems in the weeks and months after surgery. Recent studies vary greatly in methods of evaluation and diagnosis of POCD, and the pathogenic mechanisms are still unclear. The investigators evaluated a large uniform cohort of elderly patients in a standardized approach after total knee replacement.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

65 Years to No maximum

Healthy volunteers

Inclusion criteria

* aged ≥65 years; * ASA I or Ⅱ; * total knee replacement

Exclusion criteria

* Mini Mental State Examination \[MMSE\] score too low. * Parkinson or other neurological disease causing functional impairment. * Patients with a history of alcohol abuse (≥35 U per week) or daily use of anxiolytics were also excluded, as well as those with severe hearing or visual impairment.

Design outcomes

Primary

Measure	Time frame
Effects of operation on early postoperative cognitive function in elderly patients	up to 7days postoperatively

Secondary

Measure	Time frame
Postoperative cognitive dysfunction (POCD) was defined by Mini-Mental State Examination (MMSE) score	up to 7days postoperatively

Other

Measure	Time frame	Description
serum concentration of inflammatory cytokine	The blood samples were reserved before anesthesia induction and 24h after surgery	The blood samples were reserved before anesthesia induction and 24h after surgery for detecting the concentrations of IL-1, IL-6, and IL-10 by enzyme-linked immunosorbent assay (ELISA).

Outcome results