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High-intensity Interval Versus Combined Exercise Training in CHF

High-intensity Interval Versus Combined High-intensity Interval and Strength Exercise Training in Chronic Heart Failure

Status
UNKNOWN
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT02387411
Enrollment
30
Registered
2015-03-13
Start date
2010-05-31
Completion date
2015-06-30
Last updated
2015-03-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Heart Failure

Keywords

heart failure, aerobic exercise, strength training, cardiopulmonary rehabilitation, high-intensity exercise training

Brief summary

Chronic heart failure (CHF) is a clinical syndrome presented with central, cardiac deterioration as well as peripheral vascular and muscular abnormalities, resulting finally to reduced exercise tolerance, quality of life and mortality rates. Exercise training is a major component of rehabilitation / secondary prevention interventions, inducing significant beneficial changes in mechanisms of pathophysiology, exercise tolerance, functional capacity and quality of life, while a positive impact on hospitalization and mortality reduction should not be also excluded. There has been growing interest in the characteristics and modalities of exercise training able to induce optimal benefits. High intensity and interval mode have been shown to induce greater benefits than moderate intensity and continuous mode regimes. Additionally, there has been sound rationale for the inclusion of strength training, which has been also shown able to yield benefits in terms of exercise capacity and quality of life. However, there haven't been much data on the so called combined regimes, which include both aerobic exercise and strength training. This study aims at investigating the effects of combined high-intensity interval and strength training compared to high-intensity interval exercise alone in CHF.

Interventions

High-intensity interval exercise training \[4 reps \* (4 min at 80% VO2peak + 3 min at 50% VO2peak)\]

High intensity \[2 reps \* (4 min at 80% VO2peak + 3 min at 50% VO2peak)\] and strength exercise training (2-4 sets, 10-12 reps, 60-65% 1RM, for quadriceps and hamstrings, 14 min in total)

Sponsors

University of Athens
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No

Inclusion criteria

* stable heart failure * ejection fraction \<=45% * optimal medical treatment * NYHA class \<=III

Exclusion criteria

* contraindications for maximal cardiopulmonary exercise testing (CPET) * moderate to severe COPD * inability to follow exercise programs due to orthopaedic problems

Design outcomes

Primary

MeasureTime frame
aerobic exercise capacity (assessed by cardiopulmonary exercise testing)3 months

Secondary

MeasureTime frame
strength exercise capacity (assessed by 1-repetition maximum test)3 months
quality of life (assessed by MLWHF questionnaire)3 months
quadriceps local adaptations (assessed by muscle biopsies)3 months
quadriceps cross sectional area (assessed by CT)3 months

Countries

Greece

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 10, 2026