Augmented Renal Clearance, Hemorrhagic Stroke
Conditions
Brief summary
To determine the incidence and predictors of augmented renal clearance (ARC) in patients with hemorrhagic stroke.
Interventions
No interventions
Sponsors
Study design
Eligibility
Inclusion criteria
* Adults ≥ 18 years * Patients with hemorrhagic stroke * Anticipated length of stay in the neuroscience intensive care unit \> 48 hours * Informed consent provided by the patient or by the patient's designated medical proxy
Exclusion criteria
* Pregnancy * Patients with pre-existing renal dysfunction (chronic kidney disease stages 3 - 5) * Patients receiving renal replacement therapy * Patients with an admission serum creatinine \> 1.4 mg/dL * Patients with non-aneurysmal subarachnoid hemorrhage * Patients with history of nephrectomy or body mass index \< 18 kg/m2
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| To describe the onset, magnitude, and change over time of ARC in patients with hemorrhagic stroke | Over neurosciences intensive care unit stay | Daily 8-hour urine collections will be performed to directly measure creatinine clearance up to ICU discharge |
Countries
United States