Large-scale ex Vivo Expansion and Characterization of Two Kinds of MSC From Knee for Clinical Application

Large-scale ex Vivo Expansion and Characterization of Synovial Membrane MSC (SM-MSC) and Infrapatellar Fat Pad MSC (IF-MSC) for Clinical Application

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02386163

Enrollment

Registered

2015-03-11

Start date

2014-05-31

Completion date

2015-08-31

Last updated

2015-09-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Knee Injuries

Brief summary

According to many researches, mesenchymal stem cells (MSC) isolated from synovial membrane and infrapatellar fat pad have higher ex vivo proliferation capacity, multipotency and ability to undergo chondrogenesis. Based on this concept, the investigators plan to get two removed tissues (synovial membrane and infrapatellar fat pad) from patients who have an operation of TKR (Total Knee Replacement). The investigators are going to isolate and expand MSC from these two tissues respectively, and then compare their characterization and potential for clinical application. In the other hand, the investigators plan to build techniques and procedures which comply with Good Tissue Practices (GTP).

Interventions

BIOLOGICALMSC from synovial membrane and infrapatellar Fat Pad

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

20 Years to No maximum

Healthy volunteers

Inclusion criteria

Patient who have an total knee replacement surgery

Exclusion criteria

Patient who don't sign the agreement

Design outcomes

Primary

Measure	Time frame	Description
Compare MSCs from synovial membrane and infrapatellar fat pad	2 months	Comparison items include doubling time, phenotype, chondrogenesis and biological activity.

Countries

Taiwan

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026