Chronic Periodontitis
Conditions
Brief summary
The present study is designed to investigate the effectiveness of AV gel local drug delivery as an adjunct to scaling and root planing (SRP) in the treatment of subjects with chronic periodontitis (CP) and type 2 diabetes mellitus (DM).
Detailed description
BACKGROUND: Advances in the field of alternative medicine have promoted widespread use of herbal agents, like Aloe vera (AV), for both medical and dental therapy. AV has anti-inflammatory, antioxidant, antimicrobial, hypoglycaemic, healing promoting and immune boosting properties. The present study is designed to investigate the effectiveness of AV gel local drug delivery as an adjunct to scaling and root planing (SRP) in the treatment of subjects with chronic periodontitis (CP) and type 2 diabetes mellitus (DM). MATERIAL AND METHODS: A total of 60 subjects with probing depth (PD) ≥5mm and clinical attachment level (CAL) ≥3mm were randomly divided into two groups. Group 1 was treated with SRP + placebo gel local drug delivery (LDD) and Group 2 with SRP + AV gel LDD. Clinical parameters including full mouth plaque index (PI), modified sulcus bleeding index (mSBI), probing depth (PD) and clinical attachment level (CAL) were recorded first at baseline and then at intervals of 3 months and 6 months.
Interventions
DRUGaloe vera
After SRP, aloe vera gel was delivered subgingivally into periodontal pockets.
DRUGplacebo gel
After SRP, placebo gel was delivered subgingivally into periodontal pockets.
Sponsors
Government Dental College and Research Institute, Bangalore
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
25 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* Well-controlled type 2 DM * Chronic periodontitis with moderate to deep pockets \[probing depth (PD) ≥5mm and clinical attachment loss (CAL) ≥3mm\] * No history of antibiotic or periodontal therapy in the preceding 6 months.
Exclusion criteria
* Any known disease/condition or on any medication that can affect the periodontal status * Known or suspected allergy to herbal medications * Systemic antimicrobial therapy * Aggressive periodontitis * Smokers * Alcoholics * Immunocompromised patients * Pregnant or lactating females
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in Clinical attachment level | baseline to 6 months |
Secondary
| Measure | Time frame |
|---|---|
| Change in Plaque index | baseline to 6 months |
| Change in modified sulcus bleeding index | baseline to 6 months |
| Change in Probing depth | baseline to 6 months |
Outcome results
None listed