Major Depressive Disorder
Conditions
Keywords
mindfulness-based cognitive therapy, depression, treatment, mindfulness meditation, psychotherapy
Brief summary
This study will investigate the efficacy of an 8-week course in Mindfulness-Based Cognitive Therapy (MBCT) for adults with major depressive disorder (MDD) by ;measuring change from baseline to completion of treatment at 8 weeks in terms of depression severity using the Hamilton Depression Ratings Scale. We will measure change in C-Reactive Protein, a measure of inflammation, over the same time period.
Detailed description
This study will investigate the effectiveness of MBCT as a primary treatment for MDD. Twelve unmedicated subjects with MDD were enrolled in the study. All subjects with MDD underwent depression severity assessment at baseline and after the 8-week intervention was complete to measure change. In addition, the subjects underwent blood sampling at the same time points to measure C-Reactive Protein change over the 8 weeks. The primary goal of this pilot study is to determine the efficacy of MBCT as a primary treatment for adults with MDD. We will also measure change in the inflammatory biomarker C-Reactive Protein for an examination of the effects of depression treatment on this measure.
Interventions
BEHAVIORALMindfulness-Based Cognitive Therapy
Eight week course in mindfulness meditation training with elements of cognitive behavioral therapy
Sponsors
University of California, San Francisco
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* English speaking * Able to give informed consent * DSM-IV (SCID) Diagnosis of Major Depression * HAM-D17 score ≥ 17 * Good general medical health; no active significant uncontrolled medical illness * Free of antidepressant medication for a minimum of 6 weeks before study entry * Not needle phobic by self report
Exclusion criteria
* Axis I and II disorders including: Bipolar, Obsessive Compulsive Disorder, Psychosis, or Antisocial or Borderline Personality Disorder with suicidal risk * Major Depression with Psychotic Features * Actively suicidal * Recent (6 month) history of substance or alcohol dependence (DSM-IV criteria) * Meditation practice once or more per week * Yoga practice more than twice per week at study entry * Mini Mental Status Exam score \< 25or history of neurologic illness
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Hamilton Depression Rating Scale Change with MBCT treatment | Week 0, 8 | 17-item clinician-rated measure of depression severity. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| C-Reactive Protein (Blood) Change with MBCT treatment | Week 0-8 | An inflammatory biomarker that varies with levels of inflammation in the body |
Countries
United States
Outcome results
None listed