Comparing the Use of Dienogest and Combined Oral Contraceptive Pills (Microgynon) to Reduce the Risk of Recurrence of Endometriotic Cyst After Conservative Surgery

A Prospective, Randomized Controlled Trial Comparing the Use of Dienogest and Combined Oral Contraceptive Pills (Microgynon) to Reduce the Risk of Recurrence of Endometriotic Cyst After Conservative Surgery

Status

UNKNOWN

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02385448

Enrollment

144

Registered

2015-03-11

Start date

2015-02-28

Completion date

2019-02-28

Last updated

2015-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Endometriosis

Keywords

dienogest, combined oral contraceptive pills, endometriosis

Brief summary

The purpose of the study is to compare the recurrence of endometriotic cyst in patients taking Dienogest or Microgynon after conservative surgery.

Interventions

DRUGDienogest

The dienogest group will receive dienogest 2mg daily for 24 months postoperatively

DRUGMicrogynon

The combined oral contraceptive pills group will be given cyclical Microgynon for 24 months.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

NONE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 51 Years

Healthy volunteers

Inclusion criteria

* Good general health * Older than the age of legal consent (i.e. 18 years old) * Sonographic diagnosis of ovarian endometrioma with diameter at least 4cm on 2 separate scans at least 6 weeks apart * No contraindication to use of progesterone or combined oral contraceptive pills * Not attempting to conceive either at the time of study entry or for at least 2 years after surgery * Willing and able to participate after the study has been explained

Exclusion criteria

* Operative findings not suggestive of endometriotic cyst * Contraindications to progestogens or oral contraceptive pills * Unwillingness to tolerate menstrual irregularity * Planning pregnancy within 2 years of study * Cannot understand English, Cantonese or Putonghua

Design outcomes

Primary

Measure	Time frame	Description
Recurrence of ovarian endometrioma	2 years	Time to recurrence by sonography (months)

Secondary

Measure	Time frame	Description
Side effects	2 years	Days of irregular bleeding
Symptoms of endometriosis	2 years	Pain by visual analog score
Need for additional analgesics	2 years	Types of analgesics used

Countries

Hong Kong

Contacts

Primary ContactJennifer K.Y. Ko, MBBS, MRCOG

jenko@hku.hk852 22554647

Backup ContactMan Wa Lui, MBBS, MRCOG

luimanwa@gmail.com852 22554647

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026