Food Allergies
Conditions
Brief summary
Reintroduction of small doses of food in allergic children to lightening the elimination diet.
Detailed description
In four groups of allergic children (peanuts, wheat , milk and egg), a reintroduction of 4 small increasing doses of allergen is carried out progressively double-blind placebo- cons , randomized, during a hospitalization. The procedure for reintroduction of small doses (MPD) is stopped at the appearance of intolerance (in taking a dose of allergen or placebo) defined by the onset of allergic symptoms or objective severe abdominal pain within 45 minutes of taking.
Interventions
OTHERallegic food
Reintroduction procedure for small doses : * Administration of the first dose * Clinical monitoring for 45 minutes * Administration of the second dose
OTHERPlacebo
Sponsors
University Hospital, Angers
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
9 Months to 16 Years
Healthy volunteers
No
Inclusion criteria
* Allergic children 1 and 16 years for peanut, egg and wheat. So, for milk between 9 months and 16 years. * Accurate diagnostic * Allergic react rapidly and acute
Exclusion criteria
* severe disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Tolerance for each ingested dose is assessed by a clinical score | 45 minutes | Tolerance is defined by the absence of allergy symptoms within 45 minutes of ingestion of the allergen dose in the absence of intolerance to previous placebo |
Countries
France
Contacts
Primary ContactMartine Drouet
Outcome results
None listed