Hyperoxia
Conditions
Keywords
Lung Volume Measurements, airway resistance, general anesthesia
Brief summary
This study is aiming at assessing the effect of inspired oxygen fraction during general anesthesia on children's lung mechanics and volume. More specifically, the temporal change in end-expiratory lung volume (EELV) and respiratory system resistance and elastance during the perioperative period will be characterized in order to define the the effect of high inspired fraction of oxygen on lung function.
Detailed description
High-enriched oxygen fractions (FiO2)are common practice during general anesthesia both to ensure normoxemia despite intrapulmonary shunts and to provide security in case of adverse events. However, high-inspired oxygen fraction may decrease ventilation-perfusion ratios and its benefits are still unproven in children. The investigators aim at assessing the benefits and potential adverse effects of high-inspired oxygen fraction in two groups of children receiving either 30% FiO2 or 80% FiO2 during maintenance of anesthesia. Nitrogen multiple breath washout technique and forced oscillation technique will be used to measure end-expiratory lung volume (EELV) and airway resistance (Rrs) and respiratory elastance (Xrs) respectively. These measurements will be obtained before the general anesthesia, one hour and one day after the procedure.
Interventions
OTHEROxygen
Delivery of high concentration of oxygen at induction, maintenance and extubation of children under general anesthesia.
Sponsors
Walid HABRE
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
4 Years to 16 Years
Healthy volunteers
Yes
Inclusion criteria
* American Society of Anesthesiology (ASA) physical status I and II * Body mass index \< 30 kg/m2 * Scheduled for elective surgery in the supine position lasting \< 200 min * General Anesthesia with tracheal intubation
Exclusion criteria
* Patients hospitalized more than 24 h before the operation * History or clinical signs of heart or lung disease * Upper respiratory tract infection \< 2 weeks prior to surgery * Predictable difficult airway * History of apnea * Abdominal or thoracic surgery * Lack of cooperation, language barrier
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Postoperative changes in lung volume in children receiving low (35%) or high (80%) intraoperative fraction of oxygen | 24 hours | Measurement of end-expiratory lung volume by nitrogen wash-out technique |
| Postoperative changes in airway resistance in children receiving low (35%) or high (80%) intraoperative fraction of oxygen | 24 hours | Measurement of airway resistance and respiratory system elastance by forced oscillation technique |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Respiratory complications | 1 month | Assessing intraoperative (bronchospasm, laryngospasm, oxygen desaturation, airway obstruction) and postoperative (hypoxemia, atelectasis, pneumonia) complications |
| Postoperative nausea and vomiting | 24 hours | — |
Other
| Measure | Time frame |
|---|---|
| Surgical site infection | 1 month |
Countries
Switzerland
Outcome results
None listed