Type 2 Diabetes Mellitus
Conditions
Brief summary
Background/Aims: Verify the effects of glycemic index (GI) on body composition, and on inflammatory and metabolic markers concentrations. Methods: Eighteen type 2 diabetics, (aged 42.4 + 5.1 years, BMI 29.2 + 4.8 kg.m-2) were randomly allocated to low GI (LGI) or high GI (HGI) groups. High or low GI meals were provided in the laboratory twice a day during 30 consecutive days. The other meals were consumed under free living condition and subjects were instructed to select foods presenting GI values corresponding to the allocated group. Body composition (body mass index, body fat percentage, waist circumference and waist-hip ratio), and inflammatory markers concentrations (interleukin-6, tumor necrosis factor-alpha, high molecular weight adiponectin, ultra-sensitive C-reactive protein and fibrinogen) and metabolic markers (glucose, insulin, total cholesterol, HDL cholesterol, free fatty acids, triglycerides and fructosamine) were assessed at baseline and after intervention. Food intake was monitored during the study. The criterion for statistical significance was P\<0.05.
Interventions
DIETARY_SUPPLEMENTLow GI index diet
Low glycemic index diet
DIETARY_SUPPLEMENTHigh GI diet
High glycemic index diet
Sponsors
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior.
Fundação de Amparo à Pesquisa do estado de Minas Gerais
Federal University of Vicosa
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
20 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
* Type 2 diabetes mellitus * Level of physical activity light to moderate * Use of sulfonylureas or biguanides oral hypoglycemic drugs * Stable medications for the previous 3 months
Exclusion criteria
* Cardiovascular, renal, or liver disease * Treatment for cancer * Smokers * Daily consumption of \> 50g/day of alcohol * Pregnant, lactating, postmenopausal women, * Hormone replacement therapy * Recent change (last three months) in the level of physical activity or diet * Weight instability (\> 3 kg in the previous three months), * Therapeutic diet * Allergies, test foods intolerance * Use of drugs affecting body metabolism and/or food intake.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Body fat content determined by tetrapolar bioelectrical impedance . | 30 days |
Countries
Brazil
Outcome results
None listed