Diabetes, Pregnancy
Conditions
Brief summary
The aim of the research is to study the effect of miRNA, fat tissue and insulin resistance on the pathophysiology of diabetes during pregnancy. During the study fat tissue, Umbilical cord blood, placenta tissue and subcutaneous fat will be taken from pregnant diabetic woman over going a C-section. Healthy pregnant women will serve as a control group.
Detailed description
The aim of the research is to study the effect of miRNA, fat tissue and insulin resistance on the pathophysiology of diabetes during pregnancy. During the study: 1. fat tissue, Umbilical cord blood, placenta tissue and subcutaneous fat will be taken from pregnant diabetic woman over going a C-section. 2. Bloods will be analyzed for insulin, c-peptide, glucose and fat profile 3. Placenta and fat tissue will be analyzed for miRNA and total RNA 4. Clinical and anthropometric measurements will be taken from the mother 5. Placenta status will be taken
Interventions
OTHERDiabetes
the trial is observational with no intervention
Sponsors
Hadassah Medical Organization
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* age 18-45 * pregnant * signed consent form * going through an elective C-section * Diabetic * reference group: healthy women with no background illness
Exclusion criteria
* \<18 or \>45 * chronic illness that may effect the outcome * polypharmacy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| miRNA profiling | samles are taken during C-section samples will be analyzed after completion of collection |
Contacts
Primary ContactUriel Elchalal, Proffessor
Outcome results
None listed