Tinnitus, Subjective
Conditions
Keywords
Adult, Aged, Alpha Rhythm, Auditory Cortex, Chronic, Electroencephalography, Female, Humans, Male, Neurofeedback, Prospective Studies, Questionnaires, Tinnitus, Treatment Outcome
Brief summary
Chronic tinnitus affects about 10-15% of the population in industrialized countries. Investigations of the brain activity by using electroencephalography (EEG) showed that in localized regions of the hearing system brain activity was decreased. This reduction of activity is thought to be one of the reasons that keep the perception of the tinnitus going. Recent studies have shown that neurofeedback is a viable option for treatment of chronic tinnitus. By using neurofeedback it is possible to train brain functions by the simple principle of rewarding wanted changes and punishing unwanted ones. The purpose of the investigators study is to show the efficacy of specific localized neurofeedback training in comparison to global relaxing neurofeedback training. In order to achieve decreased tinnitus symptoms or even disappearance of the tinnitus, 15 neurofeedback trainings are planned. Before and up to 6 month after the training EEG-recordings are performed.
Interventions
DEVICETomographic Neurofeedback
EEG-Electrodes are placed on the patients head to record the brain activity, EEG-recordings are processed by the standardized Low Resolution Brain Electromagnetic Tomography algorithm (sLORETA) to calculate the frequency spectrum in the auditory cortex and deliver feedback for the patient
DEVICENon Tomographic Neurofeedback
EEG-electrodes are placed on the patients head, but only 4 electrodes (Fc1, Fc2, F3 and F4 of a 10-10 EEG-system) record the surface activity and generate the feedback for the patient.
Sponsors
University of Zurich
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Age 18-75 * Chronic Tinnitus \> 0.5 years * Informed Consent * Fluent in German language
Exclusion criteria
* Psychological and neurological disorders other than tinnitus * Drug- or Alcohol abuse * Tranquilizer, antiepileptic drugs, antipsychotics or anesthetics intake * Impairing hearing loss or Cochlea Implant
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change from Baseline in Tinnitus symptoms assessed by questionnaires | at 1, 3, 6 month follow up | Assessement of the Tinnitus symptoms before and after the Treatment with neurofeedback by different questionnaires tailored for Tinnitus and Quality of life. |
| Change from Baseline in delta (3-4Hz) and alpha (8-12Hz) frequency band EEG-activity in the auditory cortex | at 1, 3, 6 month follow up | EEG recordings of the trained frequency bands are compared before and after the Intervention in the named time periods |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Difference in efficacy between Tomographic Neurofeedback (TONF) and Non Tomographic Neurofeedback (NTE) in treatment of tinnitus assessed by tinnitus questionnaires and frequency band EEG-activity measurements (3-4Hz and 8-12Hz) compared to Baseline. | at 1, 3, 6 month follow up | Investigation if there is a significant benefit in the TONF Group, compared to the non tomographic Group. |
Countries
Switzerland
Outcome results
None listed