Remifentanil for the I-gel and Laryngeal Mask Airway Insertion

Comparison of the Effect-site Concentration of Remifentanil for Insertion of the I-gel and Laryngeal Mask Airway During Propofol Anesthesia

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02382354

Enrollment

Registered

2015-03-06

Start date

2015-03-31

Completion date

2015-09-30

Last updated

2015-10-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Supraglottic Airways for General Anesthesia

Brief summary

Structural differences of supraglottic airway devices could influence the different compressive forces in the oropharyngeal cavities, and require different depth of anesthesia. The addition of remifentanil during propofol anesthesia facilitates the insertion of laryngeal mask airway (LMA) with minimal adverse hemodynamic disturbances. This study was designed to determine the effect-site concentration of remifentanil in 50% of patients (EC50) and 95% of patients (EC95) for successful i- gel insertion, and compare those for LMA insertion during propofol target-controlled infusion (TCI).

Detailed description

Anesthesia was induced with propofol TCI at the effect-site concentration of 5 μg/ml, and the predetermined effect-site concentration of remifentanil was started simultaneously. The remifentanil concentration was determined using modified Dixon's up-and-down method (initial concentration: 3.0 ng/ml, step size: 0.5 ng/ml). Five minutes later, i- gel or LMA insertion was attempted. The response of the patients to the insertion of LMA was classified as either 'movement' or 'no movement'.

Interventions

DRUGremifentanil

The predetermined effect-site concentration of remifentanil was started using modified Dixon's up-and-down method

DEVICEi-gel

I-gel insertion was inserted 5 min after anesthesia induction

DEVICElaryngeal mask airway

laryngeal mask airway insertion was inserted 5 min after anesthesia induction

DRUGpropofol

Anesthesia was induced with propofol target-controlled infusion at the effect-site concentration of 5 μg/ml

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

FEMALE

Age

19 Years to 60 Years

Healthy volunteers

Inclusion criteria

* ASA I-II patients undergoing general anesthesia for short elective surgery (\<2 hr)

Exclusion criteria

* G-E reflux * obesity (BMI\>30) * anticipated difficult airway

Design outcomes

Primary

Measure	Time frame
successful insertion of i-gel and LMA	from 5 min after anesthetic induction to 1min after device insertion

Countries

South Korea

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026