Accuracy of Non-invasive Effective Pulmonary Perfusion Measurement by CO2

Accuracy and Precision of Non-invasive Effective Pulmonary Perfusion Measurement Using Volumetric Capnography

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02382120

Enrollment

Registered

2015-03-06

Start date

2015-03-02

Completion date

2018-07-21

Last updated

2018-08-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiovascular Disease

Keywords

carbon dioxide, cardiac output, ventilation, thermodilution

Brief summary

Cardiac output monitoring is mandatory in most surgical and critical care patients. Many techniques to assess cardiac output are invasive and/or have many limitations, contraindications and drawbacks. The measurement of cardiac output throughout the CO2 signal is an interesting option due to the simplicity and non-invasive nature of its calculation. The present study was designed to compare the cardiac output measurement using a capnodynamic formula versus the reference thermodilution method.

Detailed description

This is a prospective and observational study designed to test the accuracy and precision of the non-invasive capnodynamic cardiac output measurement in mechanically ventilated patients. We will study 30 patients undergoing cardiovascular by pass in which an invasive trans-thoracic thermodilution method (PICCOScience) is indicated - the reference method. A pair of thermodilutions and capnodynamic cardiac output measurement will be performed along the surgery. Analysis of precision will be done at the begining of the protocol and during stable hemodynamic conditions. Accuracy will then assessed using the Bland-Altmann plot and regression analysis.

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

50 Years to 80 Years

Healthy volunteers

Inclusion criteria

* Written informed consent * Programmed cardiac surgeries * Surgeries with cardiopulmonary bypass

Exclusion criteria

* Emergency surgeries. * Acute pulmonary diseases * Contraindication of femoral catheters. * Need of counter-pulsation baloon

Design outcomes

Primary

Measure	Time frame	Description
Accuracy and precision of capnodynamic to measure cardiac output	8 months	Comparison between a reference method (thermodilution) with a new one (capnodynamics)

Countries

Argentina

Outcome results