Malignant Neoplasm of Stomach
Conditions
Keywords
gastric cancer, intraperitoneal chemoperfusion
Brief summary
Patients with histological proven advanced gastric cancer (including cancer of the esophagogastric junction (AEG) without evidence of distant metastases, who fulfill the inclusion and exclusion criteria, can be recruited in this study. There are two treatment groups (A and B). The D2 radical gastrectomy will be applied in both groups. Patients randomized into group B will be treated with an intraperitoneal (in the abdominal cavity) chemoperfusion with cisplatin(75mg/m2 max 150mg/m2 max 5L ). Patients randomized into group A will not accept intraperitoneal chemoperfusion. Patients in both groups receive 6 cycles of postoperative chemotherapy (SOX or XELOX) within 4-12 weeks after the surgical procedure and are followed up for 24 months.
Detailed description
The objective of the trial is to compare the treatment of patients with advanced gastric cancer without evidence of distant metastases treated with D2 radical gastrectomy and intraperitoneal chemoperfusion (HIPEC) and postoperative chemotherapy (Group B) and patients treated with D2 radical gastrectomy alone and postoperative chemotherapy (Group A). The hypothesis of the trial is that D2 radical gastrectomy with intraperitoneal chemoperfusion (Group B) is superior to D2 radical gastrectomy (Group A) in terms of overall survival. The trial is designed as a prospective, randomized, open, multicenter and parallel group study.
Interventions
PROCEDUREintraperitoneal chemoperfusion
HIPEC with cisplatin at the time of D2 radical surgery
Sponsors
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Histological proved diagnosis of peritoneal metastasized gastric cancer including carcinoma of the AEG. * No evidence of distant metastases * preoperative examination (CT/MRI) demonstrated resectable gastricc cancer with T3-T4 stage * Written informed consent is obtained prior to commencement of trial treatment
Exclusion criteria
* Any previous chemotherapy or radiotherapy, and any investigational treatment for gastric cancer * Active systemic infections * Patients with known interstitial lung disease with New York Heart Association classification \> 2 * Serious cardiac dysrhythmia or condition, New York Heart Association classification of III or IV, congestive cardiac failure * cardiac arrhythmia * Inadequate renal function at the beginning of the trial, defined as GFR less than \<60 ml/min * Inadequate liver function at the beginning of the trial, defined as Bilirubin \>1.5 times ULN * Inadequate bone marrow function at the beginning of the trial, defined as platelet count less than \<150 GPT/L or neutrophil granulocyte count less than \<1.5 GPT/ * Active vaccination within 6 weeks prior to randomisation * Active hepatitis B or C infection * Female patients who are pregnant or breast feeding * Missing of capacity to contract * contraindication to the drugs which are used in the trial * Participation in another therapeutic clinical trial
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| overall survival | 24 months | overall survival \[ Time Frame: Death or 2 years \] |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| complication rate | 30 days | — |
| time to progress | 24 months | follow up every 3 months till 24 months end of study |
| time to distant metastasis | 24 months | time to other distant metastases follow up every 3 months till 24 months |
Countries
China
Contacts
Primary ContactMeng Wang
Backup ContactWenxian Guan
Outcome results
None listed