Down Syndrome
Conditions
Brief summary
The main aims of the present project include 1) to study the longitudinal effects of whole-body vibratory exercise on bone metabolism in adolescents with and without DS and 2) to evaluate whether a low frequency vibratory training program consisting of 3 sessions per week for 9 months (each vibratory session last approximately 10 minutes and includes 5-6 bouts of 1 min with 1 min rest between bouts) can improve bone development in these populations. Finally, and additional aim of the project is 3) to determine how long these effects may last after the end of the intervention.
Interventions
DEVICEWhole-body vibration training (Power Plate®) on bone mass and bone metabolism in adolescents with and without Down syndrome.
Sponsors
Universidad de Zaragoza
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
10 Years to 19 Years
Healthy volunteers
Yes
Inclusion criteria
* Both groups: Ages 10 - 19. * Both groups: Parental/guardian permission (informed consent) and if appropriate, child verbal assent. * Down syndrome group only: Diagnosis of Down syndrome.
Exclusion criteria
* Taking medication affecting bone. * Non-caucasian.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes from baseline in body composition assessed with dual energy X-ray at different time points, 6 months and 15 months. | Changes from baseline in body composition at 6 months and changes from baseline in body composition at 15 months |
Secondary
| Measure | Time frame |
|---|---|
| Changes from baseline in bone structure evaluated with peripheral quantitative computed tomography at different time points, 6 months and 15 months. | Changes from baseline in bone structure at 6 months and changes from baseline in bone structure at 15 months |
Countries
Spain
Outcome results
None listed