Dyslipidemia
Conditions
Keywords
High level of Lp(a)
Brief summary
To evaluate the effects of H.E.L.P. apheresis on lipid profile, Lp(a) level, and some inflammatory adypocytokines in patients with high cardiovascular risk.
Interventions
PROCEDUREH.E.L.P. apheresis
High cardiovascular risk patients will undergo H.E.L.P. apheresis procedure every 3 weeks for 1 year.
Sponsors
Fondazione IRCCS Policlinico San Matteo di Pavia
University of Pavia
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* high Lp(a) not responsive to diet and pharmacological treatment
Exclusion criteria
* heart failure * hepatic failure * renal failure
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Lp(a) reduction | 1 year | We will evaluate the efficacy of apheretic technique through the reduction of Lp(a) in the plasma sample expressed by mg/dL. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Inflammatory adypocytokines | 1 year | We will evaluate the efficacy of apheretic technique through the improvement of inflammatory adypocytokines in the plasma sample. |
Other
| Measure | Time frame | Description |
|---|---|---|
| Lipid profile | 1 year | We will evaluate the efficacy of apheretic technique through the reduction of total cholesterol, LDL and HDL cholesterol, and triglycerides in the plasma sample expressed by mg/dL. |
Countries
Italy
Outcome results
None listed