Innovation in Endobronchial Sampling

Innovation in Endobronchial Sampling : Integration of Virtual Bronchoscopic Navigation in the Current Diagnostic Algorithm and the Use of Micro-CT for Tissue Analysis

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02380326

Enrollment

Registered

2015-03-05

Start date

2015-10-31

Completion date

2021-12-31

Last updated

2018-05-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diffuse Interstitial Lung Disease

Brief summary

Evaluating an integrated diagnostic work-up of virtual navigation bronchoscopy (VNB), confocal laser endomicroscopy and micro computerized tomography (micro-CT) in the diagnostic path of pulmonary lesions in the non-oncological patient.

Detailed description

The region(s) of interest that has/have to be sampled, will be selected upfront. Guided by the endobronchial pathway that is created by virtual bronchoscopy, the flexible bronchoscope will be navigated to the regions of interest and an optical biopsy of the region will be obtained using pCLE. One biopsy sample will be processed in the endoscopy suite to be able to prepare it for micro-CT analysis.

Interventions

PROCEDUREAdvanced endoscopic imaging modalities

Virtual bronchoscopic navigation, confocal laser endomicroscopy, micro CT

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 75 Years

Healthy volunteers

Inclusion criteria

* Presence of diffuse pulmonary disease necessitating bronchoscopic evaluation. * Informed consent available * Age \> 18 * FVC \> 50%pred * DLCO \> 35%pred * PaO2 \> 55 mmHg, pCO2 \< 45 mmHg (ambient air) * No

Design outcomes

Primary

Measure	Time frame
Diagnostic yield	postprocedural

Countries

Belgium

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026