Bioavailability of Carotenoids and Flavonoids From Fresh Oranges and Orange Juice.

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02380144

Enrollment

Registered

2015-03-05

Start date

2014-01-31

Completion date

2017-07-31

Last updated

2016-11-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy

Keywords

carotenoid, bioavailability, beta-cryptoxanthin, flavonoid, hesperidin, narirutin, randomized cross-over, Pharmacokinetics, micronutrients, Oranges/Orange Juice

Brief summary

The study was designed as a randomized 2-way cross-over study to assess the bioavailability of carotenoids and flavonoids from sweet oranges and orange juice. Volunteers followed a wash-out period for 2 weeks prior to eating either 400 g of fresh oranges or 719 g of orange juice. The amount of test food was adjusted to deliver an equal amount of β-cryptoxanthin (740 µg). After a consecutive wash-out period of 2 weeks, the procedure was repeated and the volunteers ingested the complementary test food. Blood samples were collected at 8 time points up to 9.5 h after test meal consumption. Additionally, 24 h-urine was collected to evaluate flavonoid recovery.

Interventions

OTHERFresh orange fruit and pasteurized fruit juice

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

23 Years to 30 Years

Healthy volunteers

Yes

Inclusion criteria

* Healthy adult men and women * BMI: 17-60 * Age: 18-65

Exclusion criteria

* Women who are lactating or pregnant or plan to be pregnant * Individuals using tobacco products * Individuals with metabolic or malabsorption disorders * Individuals with a history of cancer * Individuals with a history of liver insufficiency * Individuals with a history of chronic and lipid metabolism-related diseases * Individuals with an allergy to oranges * Obese individuals (BMI \> 30)

Design outcomes

Primary

Measure	Time frame
Mean AUC (nmol/L*9.5 h) of beta-cryptoxanthin concentration in blood plasma chylomicrons after ingestion of fresh oranges and orange juice, respectively.	0 - 9.5 h after each intervention

Secondary

Measure	Time frame
Mean AUC of hesperidin- and narirutin-metabolite concentration in blood plasma after ingestion of fresh oranges and orange juice, respectively.	0 - 9.5 h after each intervention
Mean hesperetin and naringenin concentration (µmol/L) in 24 h-urine after ingestion of fresh oranges and orange juice, respectively.	0 - 24 h after each intervention

Countries

Germany

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026