Congenital Heart Disease
Conditions
Keywords
Univentricular heart defect, Fontan circulation
Brief summary
Cross-sectional study of a national cohort of adolescents with univentricular congenital heart defects and Fontan type palliation.
Detailed description
A study group of 40-50 individuals will be investigated by non-invasive and invasive methods, including echocardiography at rest and during exercise, heart catheterization with advanced hemodynamic studies, cardiac and abdominal MRI, abdominal ultrasound and transient elastography, quality of life assessment and cardiopulmonary exercise testing. A selection of tests will be performed in a healthy control group as well.
Interventions
None listed
Sponsors
The Hospital for Sick Children
Oslo University Hospital
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
15 Years to 18 Years
Healthy volunteers
Yes
Inclusion criteria
* age, heart defect, heart surgery and type of palliation/correction, informed consent
Exclusion criteria
* non-consenting, contraindications or increased risk to perform study tests (i.e. metal parts prohibiting MRI, motoric impairment prohibiting CPET)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Hemodynamic status | Current at time of inclusion | Status as found by invasive and non-invasive assessment |
| Structural and functional hepatic changes | Current at time of inclusion | Status as found by non-invasive assessment |
| Cardio-pulmonary function and functional reserve | Current at time of inclusion | Status as found by non-invasive assessment |
| Quality of life and psycho-social outcome | Current at time of inclusion | Status as found by questionnaire |
Countries
Norway
Outcome results
None listed