Infertility
Conditions
Brief summary
This study evaluates the difference in pregnancy rate transferring a healthy blastocyst in natural or artificial cycle.
Detailed description
The aim of the study was to verify the implantation capacity and ongoing pregnancy rate of vitrified warmed euploid blastocyst in natural cycle versus endometrial artificial cycle with gonadotropin-releasing hormone (GnRH-agonist) pituitary suppression.
Interventions
OTHERembryo transfer
healthy blastocyst transfer in natural and hormonal cycle
Sponsors
European Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 42 Years
Healthy volunteers
No
Inclusion criteria
* frozen-thawed healthy blastocyst
Exclusion criteria
* post thawed not survival healthy blastocyst
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| clinical pregnancy rate confirmed by ultrasound evidence of fetal heart activity | 12 weeks after embryo transfer |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| live-birth rate confirmed by the number of born | term pregnancy delivery | — |
| cost-benefit of two endometrial preparation protocol | 30 weeks beginning from day 21 of the previous cycle day up to the pregnancy test | Assessment of drug cost and the count of clinical visit, laboratory dosages and venous sampling |
| The number of patients with the anxiety and depression increase | Six weeks beginning on the day of treatment start, on the day of progesterone administration, on the day of blastocyst transfer and the pregnancy test | the psychological questionnaire (HADS) administered on four time point |
Countries
Italy
Outcome results
None listed