In Vivo Quantification of Short Chain Fatty Acids Production in the Human Colon

In Vivo Quantification of Short Chain Fatty Acids Production in the Human Colon After Consumption of Different Cereal Fractions.

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02378376

Enrollment

Registered

2015-03-04

Start date

2013-07-31

Completion date

2015-02-28

Last updated

2015-03-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy

Brief summary

During this project the amount of SCFA produced in the colon after consumption of 2 different 13C-labelled wheat fiber fractions will be quantified.

Interventions

DIETARY_SUPPLEMENTArabinoxylan oligosaccharides

DIETARY_SUPPLEMENTDietary fiber enriched bran

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

BASIC_SCIENCE

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Yes

Inclusion criteria

* Regular diet with 3 meals a day (minimal 5 times a week) * BMI between 18.5 and 27 kg/m2

Exclusion criteria

* Calorie restricted diet or other special diet during the study or during the last month prior to the study * Antibiotics in the month prior to the study * Former surgeries on the gastrointestinal tract, with the exception of an appendectomy * use of the following types of medications with effects on the gastrointestinal tract during the last 2 weeks prior to the study (spasmolytica, anti-diarrhea, anti-constipation, probiotics) * Chronic disease of the gastrointestinal tract such as Crohn's disease, ulcerative colitis, irritable bowel syndrome, chronic constipation, chronic frequent diarrhea, clinically relevant lactose intolerance * Pregnancy, pregnancy desire or breastfeeding * Diabetes (type 1 and 2) * Blood donation in the past 3 months prior to the study * Abnormal hemoglobin (Hb) levels in blood, men must have a Hb level between 14.0 and 18.0 g / dL and women between 12.0 and 16.0 g / dL * Participation in studies in the past year in which radiation was used.

Design outcomes

Primary

Measure	Time frame
Quantification of acetate, propionate and butyrate production in the colon after consumption of each wheat derived fiber fraction	2 years

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026