Subfertility
Conditions
Brief summary
In this study the aim is to compare the effect of the type of anaesthetic drug used during oocyte retrieval on fertilization rates of oocytes retrieved after ovarian stimulation for in-vitro fertilization.
Interventions
DRUGPropofol
Propofol intravenous infusion for introduction and maintance of anaesthesia at doses 3-5mg depending on the total time needed for completion of oocyte retrieval
DRUGThiopental
Patients will receive thiopental in addition to fentanyl for introduction and maintanance of anaesthesia at doses 7mg. IF required patients will receive a repeat dose of 1-3mg of thiopental depending on the totla time needed to complete oocyte retrieval
Sponsors
Aristotle University Of Thessaloniki
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 45 Years
Healthy volunteers
No
Inclusion criteria
* women undergoing oocyte retrieval for IVF under general anesthesia * age ≤45 years
Exclusion criteria
* women with a known hypersensitivity to the active substance of the investigating drugs or any of their excipients
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Fertilization rate | First 24h after oocyte retrieval | The number of oocytes fertilized divided by the number of oocytes in which fertilization was attempted per randomized patient |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Number of MII oocytes | 12h after oocyte rertieval | — |
| Pregnancy rate | 14 days after embryo transfer | Patients with positive (\>20 IU/L) b-hCG test at 14 days after embryo transfer |
| Implantation rate | 40 days after embryo traansfer | Number of gestational sacs per embryos transferred per patient |
| The concentration of propofol or thiopental in the follicular fluid of the dominant (larger) follicle aspirated at oocyte retrieval | 12 hours after oocyte retrieval | — |
Countries
Greece
Outcome results
None listed