Bifidobacterium
Conditions
Brief summary
Hopefully this research can help to provide the optimal nutrition management from pregnancy so that the babies wiil born with better quality of health and reduce the morbidity and mortality. Until now, there is no data regarding probiotics in Indonesien breastmilk and the role of probiotics supplementation on pregnant women to the baby especially from inflammation pathways. The investigators hope the result of this research can help reducing infant morbidity and mortality rate in Indonesia, also has a benefit for future research.
Interventions
DIETARY_SUPPLEMENTProbiotic
OTHERPlacebo
Sponsors
Naomi Esthernita
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
SUPPORTIVE_CARE
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Healthy volunteers
Yes
Inclusion criteria
* pregnant women ,gestation age 32-34 weeks, normal pregnancy, plan to deliver spontaneously, no antibiotic * tend to give exclusive breastfeeding * want to join the research * well doing baby
Exclusion criteria
* pregnant women with pre-eclampsia,bleeding,infection,premature rupture of the membrane or other chronic disease * plan to deliver by caesarean section
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gastrointestinal microbiota examination by DNA extraction and real time PCR | 3 months |
| Examination of IL-8 in breast milk | 3 months |
| Examination of urine IFABP | 3 months |
| Calprotectin examination in stool of infants aged 3 months | 3 months |
| Alpha 1 antitrypsin | 3 months |
Countries
Indonesia
Outcome results
None listed