For Lung Transplant Recipients, For Oncologic Patients, From 5 Months Onwards, Potentially Operable Lung Tumor, Single of Bilateral Lung Transplant, With a Recent (Less Than 1 Month) VQ Scan, With Recent (Less Than 1 Month) Respiratory Functional Explorations
Conditions
Brief summary
Demonstrate the feasibility of dual energy computed tomography using Krypton as a gaseous contrast media in order to study the in vivo ventilation. Two different clinical situations will be tested : * Prediction of postoperative pulmonary function for oncologic patients * Detection of Bronchiolitis Obliterans in lung transplant recipients.
Interventions
RADIATIONSingle source dual energy compted tomography (CT750HD, General Electric, USA) with Krypton as a gaseous contrast media
Sponsors
University Hospital, Strasbourg, France
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
For oncologic patients : * Potentially operable lung tumor * With a recent (less than 1 month) V/Q scan For lung transplant recipients : * Single of bilateral lung transplant * From 5 months onwards * With recent (less than 1 month) respiratory functional explorations
Exclusion criteria
* Impossibility to follow simple orders or control one's respiration * Known Krypton hypersensitivity * History of malignant hyperthermia * Increased intracranial pressure * Minors * Pregnant Women
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Image quality on a qualitative 5 levels scale | 1 day of DECT ventilation imaging |
Secondary
| Measure | Time frame |
|---|---|
| Radiation dose | 1 day of DECT ventilation imaging |
| Image noise with measurement of signal to noise and contrast to noise ratios | 1 day of DECT ventilation imaging |
| Total examination time | 1 day of DECT ventilation imaging |
Countries
France
Outcome results
None listed