Deep Brain Stimulation (DBS) for Obsessive Compulsive Disorder (OCD): Improving Targeting Precision

Deep Brain Stimulation (DBS) for Obsessive Compulsive Disorder (OCD) in the Bed Nucleus of the Stria Terminalis (BNST): Improving Targeting Precision

Status

Recruiting

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02377375

Enrollment

Registered

2015-03-03

Start date

2015-01-31

Completion date

2025-12-31

Last updated

2024-07-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obsessive-Compulsive Disorder

Keywords

Deep Brain Stimulation, OCD

Brief summary

When comparing targeting precision between DBS in parkinsonian patients and OCD patients, an unexpected deviation from the planned targets was discovered in OCD patients (Nuttin et al., 2013). The objective of this trial is to investigate whether the use of a micro-electrode assisted technique improves targeting precision in DBS at the BNST.

Interventions

PROCEDUREMicro-assisted technique

Medtronic DBS lead 3391-28cm Medtronic electrode array microrecording 22670

PROCEDUREStandard technique

Medtronic DBS lead 3391-28cm

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

20 Years to 65 Years

Healthy volunteers

Inclusion criteria

* Diagnosis of OCD following the diagnostic and statistical manual of mental disorders-fourth edition (DSM-IV) criteria for OCD (300.3). * Failure of documented trials of pharmacotherapy, following an appropriate treatment algorithm for OCD. * Failure of documented trial of cognitive and behavioural therapy * Duration of illness: min. 5 year * Y-BOCS (Yale-Brown Obsessive Compulsive Scale) at least 30/40. * Age: 20-65 year

Exclusion criteria

* DSM-IV diagnosis on axis 2 of severe personality disorder in cluster A or B, especially in the case of heightened risk for acting-out behavior. * DSM-IV diagnosis on axis 3 of organic brain pathology or significant abnormalities on MRI. * Present or past history of psychotic symptoms. * Present substance abuse, or instable remission of substance abuses (i.e. no substance abuse during the last 12 months). * Any disorder affecting cognitive functioning, other than motor tics and Gilles de la Tourette's Syndrome * Mental retardation. A minimum threshold of cognitive skills is needed for adequate reporting on questionnaires and evaluation, and for technical handling of the instruments in a later faze.

Design outcomes

Primary

Measure	Time frame
Millimeter difference in position between planned and actual target	4 weeks after surgery

Countries

Belgium

Contacts

Primary ContactBart Nuttin, MD, PHD

bart.nuttin@kuleuven.be003216340859

Backup ContactSimon Raymaekers, MD

simon.raymaekers@uzleuven.be003216342690

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026