Muscle Atrophy
Conditions
Brief summary
A decrease in muscle mass can have a profound impact on quality of life, as it can lead to decreased strength, insulin resistance, lower basal metabolic rate and obesity. With this study we investigate whether ingesting leucine or getting a ND injection will reduce the loss of muscle mass and strength.
Interventions
BEHAVIORALInactivity
Inactivity
DRUGND
1 nandrolone decanoate injection
DIETARY_SUPPLEMENTLeu
Leucine supplements
Sponsors
Maastricht University Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
18 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy men 18-35 years * BMI between 18.5 and 30 kg/m2
Exclusion criteria
\- (Family) history of thromboembolic events * Smoking * Recent surgery (within 6 months prior to the study) * Performing progressive resistance training more than three times per week in the past year * Any back/leg/knee/shoulder complaints which may interfere with the use of crutches * Current systemic use of corticosteroids, anabolic steroids, growth hormone, testosterone, nandrolone, protein supplements, immunosuppressants or insulin, blood sugar decreasing medication or EPO * All co-morbidities interacting with mobility and muscle metabolism of the lower limbs (e.g. arthritis, spasticity/rigidity, all neurological disorders and paralysis) * Use of anti-coagulants * Pre-existing renal disease or those with a potential risk for renal dysfunction (diabetes, hypertension, reduced glomerular filtration rate) * Liver disease * Heart failure * Migraine * Allergy to nuts or soy * High blood pressure (\>140 mmHg systolic and \>90 mmHg diastolic) In case of doubt, in- or exclusion of subject will be discussed with responsible physician or principal investigator.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| CSA Quadriceps (CT scan) | 7 days | CT scan |
Secondary
| Measure | Time frame |
|---|---|
| Muscle strength as measured by 1RM test | 7 days |
| Muscle fiber type and CSA as measured by histochemistry from the muscle biopsy | 7 days |
Countries
Netherlands
Outcome results
None listed