Hyperthyroidism, Thyroid Cancer, Xerostomia
Conditions
Brief summary
Radioiodine (I-131) therapy for thyroid disease is known to decrease salivary function in adult patients. The impact of pediatric I-131 exposure on salivary function is unknown. The investigators goals are to answer this question by measuring salivary gland function before and after I-131 administration in children who receive radioiodine therapy at our hospital for thyroid disease.
Detailed description
Radioiodine (I-131) therapy for thyroid disease is known to decrease salivary function in adult patients. The impact of pediatric I-131 exposure on salivary function is unknown. The investigators goals are to answer this question by measuring salivary gland function before and after I-131 administration in children who receive radioiodine therapy at our hospital for thyroid disease. We will use a Modified Shirmer Test to measure saliva production and a questionnaire to evaluation symptoms of xerostomia.
Interventions
OTHERRadioiodine
We will determine if prior radioiodine treatment in childhood impacts salivary function or symptoms. Radioiodine treatment will have been determined by the patient's medical condition and care (NOT assigned by this research study).
Sponsors
Boston Children's Hospital
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
3 Years to 55 Years
Healthy volunteers
No
Inclusion criteria
* Patients who have been treated with radioiodine therapy * Patients who have never received radioiodine therapy (negative control group)
Exclusion criteria
* Non-English speaking subjects will be excluded due to our lack of translation support resources at this time. Of note, participation in our study cannot benefit participants in any way.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Salivary function (MST value) | 0 to 50 years after radioiodine treatment | sterile paper strip is used to measure saliva production (noninvasive testing) |
| Responses to Dry Mouth Questionnaire | At time of visit up to 4 months thereafter. | Patient questionnaire/survey |
Secondary
| Measure | Time frame |
|---|---|
| Caries history (number of caries noted in dental records) | 1 year before radioiodine administration to 4 months after study visit. |
Countries
United States
Outcome results
None listed