Effect of Remote Ischemic Preconditioning on Postoperative Complications in Visceral Surgery

A Randomized, Double- Blind Multicentric Study of the Effect of Remote Ischemic Preconditioning on Postoperative Complications in Patients Undergoing Major Minimal and Open Visceral Surgery

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02375269

Acronym

RIPC

Enrollment

526

Registered

2015-03-02

Start date

2015-03-31

Completion date

2018-03-31

Last updated

2015-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative Complication

Keywords

Visceral Surgery, Comprehensive Complication Index, Patient undergoing abdominal surgery

Brief summary

Remote Ischemic Preconditioning (RIPC) is mediated by intermittent brief episodes (5-10 minutes) of short ischemia in a limb (i.e. arm), followed by reperfusion. For this purpose in 3-4 cycles, a tourniquet is insufflated to suprasystolic pressure levels for 5 minutes and deflated for 5 minutes afterwards. The ischemic episodes are known to stimulate platelets and factors platelet dependent factors such as Serotonin and VEGF. These humoral factors have a systemic effect and have the potential to protect target organs (i.e. heart, kidney, liver) remote to the ischemic limb. The purpose of this randomized controlled study is to investigate the influence and impact of RIPC on postoperative complications in patients undergoing visceral surgery

Interventions

DEVICERIPC with a tourniquet

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

TRIPLE (Subject, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* \> 18 years * Undergoing major visceral surgery

Exclusion criteria

* \< 18 years * Pregnancy * Signs of Infection/Inflammation on upper limb * Shunt * Medical history of axillary lymph node dissection * Signs of malperfusion of upper limb (i.e. Allen Test) * Missing informed consent

Design outcomes

Primary

Measure	Time frame	Description
Postoperative Complications	30 days	Complications will be assessed by Comprehensive Complication Index and Dindo Clavien Score

Secondary

Measure	Time frame	Description
Hospital stay	30 days	—
ICU stay	30 days	—
Infection composite parameters	30 days	CRP, Procalcitonin, Leucocytes

Countries

Switzerland

Contacts

Primary ContactPatryk Kambakamba, MD

patryk.kambakamba@usz.ch0442551111

Backup ContactChristian Oberkofler, MD

christian.oberkofler@usz.ch0442551111

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026