Thromboelastogram During Total Knee Replacement

Thromboelastogram During Surgery for Total Knee Replacement With Tourniquet Application and Single Dose Tranexamic Acid

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02373969

Enrollment

Registered

2015-02-27

Start date

2011-08-31

Completion date

2012-01-31

Last updated

2016-04-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Orthopedic Procedures, Tranexamic Acid

Brief summary

Verify the changes in coagulation system during total knee replacement surgery with tranexamic acid single bolus infusion.

Detailed description

The study was set to reveal changes in the coagulation and fibrinolytic systems during total knee surgery and especially during tourniquet placement, tourniquet removal and revascularization of ischemic limb, after tranexamic acid single bolus infusion, and at post operative day 1.

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 75 Years

Healthy volunteers

Inclusion criteria

* Osteoarthrosis * TKR operation elective * ASA I-III

Exclusion criteria

* TKR due to any reason but osteoarthrosis * known coagulation problems * platelets \< 100,000/DcL * Hb \< 12 g% * past thrombo-embolic event * treatment with aspiring during last week * treatment with NSAID's during last 48 hours * malignancy * known allergy to tranexamic acid * general anesthesia

Design outcomes

Primary

Measure	Time frame
Change in coagulation status during and after surgery compared to pre-surgery	During and after surgery compared to pre-surgery
Change in fibrinolytic activity during and after surgery compared to pre-surgery	During and after surgery compared to pre-surgery

Outcome results