Bladder Cancer
Conditions
Keywords
stroke volume variation, radical cystectomy, blood loss, postoperative complications
Brief summary
The purpose of this study is to investigate the effect of stroke volume variation (SVV) guided fluid therapy on the blood loss and postoperative outcomes in radical cystectomy.
Detailed description
The purpose of this study is to investigate the effect of stroke volume variation(SVV) guided fluid therapy on the blood loss and postoperative outcomes in radical cystectomy. Patients were randomized to fluid management to maintain \<10% SVV (group A), or to undergo fluid management during radical cystectomy to maintain SVV 10-20% (group B). Intraoperative blood loss and hemodynamic parameters, perioperative laboratory data, and postoperative complications were compared between two groups.
Interventions
OTHERcrystalloid
Group A (SVV \<10%): infuse crystalloid 6-10 ml/kg/hr during surgery. Group B (SVV 10-20%): infuse crystalloid 2-4 ml/kg/hr until cystectomy, 6-10 ml/kg/hr after cystectomy
OTHERcolloid
Group A (SVV \<10%): infuse colloid 200 ml if SVV is ≥ 10%. Group B (SVV 10-20%): infuse colloid 200 ml if SVV is \> 20%
OTHERmannitol
Group B (SVV 10-20%): infuse mannitol 0.5 g/kg if SVV is \< 10%
OTHERlasix
Group B (SVV 10-20%): infuse lasix 5 mg if SVV is \< 10%
Sponsors
Asan Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
20 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Bladder cancer patients who received radical cystectomy * Patients with American Society of Anesthesiologists physical status scale classification 1, 2 * Patients who agree with written informed consent
Exclusion criteria
* Patients with history of arrhythmia, heart failure patients * Patients with history of renal failure patients * Patients with history of abdominal surgery * Patients who received emergency operation * Patients who do not agree with study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intraoperative blood loss | During operation |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Postoperative complications (cardiovascular complications, gastrointestinal complications, pulmonary complications, renal complications, infection, death) | During 30 days after operation | Postoperative complications include cardiovascular complications, gastrointestinal complications, pulmonary complications, renal complications, infection, death |
| Length of hospital stay/ICU stay | participants will be followed for the duration of hospital stay, an expected average of 30 days | — |
Countries
South Korea
Outcome results
None listed