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Water Uptake for Health in Amhara Pilot

Water Uptake for Health in Amhara Pilot

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT02373657
Acronym
WUHA
Enrollment
4068
Registered
2015-02-27
Start date
2014-04-30
Completion date
2017-05-31
Last updated
2021-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Trachoma

Keywords

trachoma, soil transmitted helminths, water, hand washing

Brief summary

Trachoma is a blinding disease caused by ocular strains of Chlamydia trachomatis. The Carter Center and Proctor Foundation have been jointly conducting trachoma research in the Goncha Siso Enese woreda of Amhara for the past 8 years, through a series of clinical trials. We have found that repeated mass administration of oral azithromycin can greatly reduce the prevalence of trachoma, but mass antibiotics have been unable thus far to eliminate infection. The World Health Organization recommends not only antibiotics for control of trachoma, but an entire SAFE strategy (Surgery for in-turned eyelids, Antibiotics, Facial hygiene promotion, and Environmental improvements such as latrines and water points). Trachoma is more common in villages and households with poor access to water and latrines, so improving the public health infrastructure is thought to be important for limiting transmission of trachoma. However, there is very little evidence to support the efficacy of installing new water points for trachoma. There has been only one previous attempt to study the role of hand dug well installation for trachoma control, and this study, conducted in Niger, found that installing wells was not effective. We now propose a project to improve the public health infrastructure of Goncha Siso Enese woreda by helping with the construction of water points (e.g., hand-dug wells) and providing hygiene education, in order to determine whether improving access to water and hygiene information will be effective for control of trachoma and soil-transmitted helminths.

Interventions

BEHAVIORALinstruction in soap-making and hygiene education

Sponsors

University of California, San Francisco
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender
ALL
Healthy volunteers
Yes

Inclusion criteria

* All residents residing in the state-teams which are randomly selected for this study.

Exclusion criteria

* Refusal of village chief (for village inclusion), or refusal of parent or guardian (for individual inclusion)

Design outcomes

Primary

MeasureTime frame
Prevalence of ocular chlamydia infection (0-5 year olds)24 months
Nasopharyngeal macrolide resistance (0-5 year olds)24 months
Prevalence of soil transmitted helminths (Ascaris, Trichuris trichiura, and hookworm) (0-5 year olds)24 months

Secondary

MeasureTime frame
Self report childhood morbidity24 months
Clinically active trachoma in children aged 0-5, as determined by the WHO simplified grading system24 months
Prevalence of enteric viruses using PCR (0-5 year olds)24 months
Childhood growth (weight controlled for height among children aged 0-5 years at baseline)24 months

Countries

Ethiopia

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026