Ageing, Photo-aging
Conditions
Keywords
Anti-aging, Isoflavones, Astaxanthine, Skin aging
Brief summary
Photoaging is caused by the superposition of chronic ultraviolet (UV)-induced damage on the intrinsic aging process, and accounts for the majority of age-associated changes in skin appearance. Reactive oxygen species (ROS) play a key role in UV-induced skin damage and diminish skin matrix protein levels, leading skin aging. Strategies utilizing endogenous skin antioxidants as well as plant-derived or synthetic compounds have been examined. Astaxanthin mainly from marine algae and crustaceans is a kind of carotenoids which were well-known photo-protective agents with strong antioxidant activity. Several studies have revealed that supplementation of astaxanthin effectively protect skin against UV damage through free radicals. In addition, matrix metalloproteinase-1 induced by UV irradiation is an important step toward skin aging. Recently, many studies pointed out that phytoestrogens exhibit agonistic and antagonistic estrogen activities, suppressing activity of MMP-1 in skin. Isoflavone is a kind of phytoestrogen from soybean and mainly act on skin and bones, inhibiting MMP-1 effectively. The present study is designed to take isoflavone combined with astaxanthin to maximize their anti-aging ability and objectively measure the effects of the mixture on facial wrinkles, hydration, and elasticity.
Interventions
Sponsors
Seoul National University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
FEMALE
Age
45 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Healthy females aged ≥ 45 years * Facial wrinkle grade 2 to 4
Exclusion criteria
* received medical or cosmetic treatment that interferes with the general aging process at least 3 months before the study * received any hormone replacement therapy at least 3 months before the study * reported taking functional foods more than 1 month during last 3 months before the study * history of acute or chronic disease such as severe liver or kidney disease * history of allergies against any component of trial foods * any visible skin disease that might be confused with a skin reaction to the test procedure
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change from baseline in skin wrinkles | Twenty-four weeks | Facial wrinkles in the crow's feet area measured by Skin Visiometer |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change from baseline in skin barrier integrity | Tewnty-four weeks | TEWL measured by Tewameter |
| Change from baseline in skin elasticity | Twenty-four weeks | Facial elasticity measured by Cutometer |
| Change from baseline in epidermal hydration | Twenty-four weeks | Skin hydration measured by Corneometer |
Countries
South Korea
Outcome results
None listed