Blood Pressure, Dietary Modification, Kidney Failure, Chronic
Conditions
Brief summary
The purpose of this study is to examine the effect of nutritional supplementation during hemodialysis treatment on beat-to-beat hemodynamics and treatment efficiency in a crossover design.
Detailed description
The consumption of food or nutritional supplements during hemodialysis treatment has been shown to improve nutritional status, improve quality of life, and reduce mortality. Despite these observations, allowing patients to eat food during hemodialysis treatment is sometimes restricted in the United States. The reasons for this restrictive policy are multi-factorial, but include concerns related to drops in blood pressure BP or a reduced efficiency of solute removal following eating during HD treatment. An alternative to eating solid food is to provide patients with liquid nutritional supplements. Clinics in the US are more likely to allow the consumption of liquid nutritional supplements, however, little is known about the effect that liquid supplements have on blood pressure or treatment efficiency. Therefore, the investigators plan to examine the effect of nutritional supplementation during hemodialysis treatment on hemodynamics and treatment efficiency in a crossover design.
Interventions
DIETARY_SUPPLEMENTNepro
Patients will be asked to consume a single 8 oz can of Nepro
Sponsors
University of Illinois at Urbana-Champaign
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
SUPPORTIVE_CARE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* Receiving hemodialysis treatment three times per week, on hemodialysis for greater than three months, receive medical clearance from a Nephrologists
Exclusion criteria
* Milk or soy allergy, more than 4 hypotensive events requiring intervention in the last two weeks, hospitalized due to hypotension in the previous week
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes in beat-to-beat systolic blood pressure | Duration of each treatment (approximately four hours), treatments will be one week apart for a total of three weeks | Beat-to-beat blood pressure will be monitored throughout the treatment by finger plethysmography |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Gastrointestinal symptoms during treatment by a rating scale | Duration of each treatment (approximately four hours), treatments will be one week apart for a total of three weeks | A validated version of the Gastrointestinal Symptom Rating Scale will be administered |
| Treatment efficiency measured by urea removal | Duration of each treatment (approximately four hours), treatments will be one week apart for a total of three weeks | Kt/V as determined from blood urea pre- and post-hemodialysis |
Countries
United States
Outcome results
None listed