Erosive Hand Osteoarthritis
Conditions
Brief summary
Hand osteoarthritis is a common phenotype of osteoarthritis which affects about 70 % of the elderly population. Usually considered as a minor illness, it nevertheless leads to an important functional impairment. The mechanism of this disease is still poorly known. Furthermore there are 2 different subtypes : erosive and non erosive hand osteoarthritis from which mechanisms may differ. Methods: This is a cross-sectional study recruiting patients with hand osteoarthritis addressed in consultation of rheumatology and plastic surgery in Rouen University Hospital. Two groups of patients will be studied: 20 patients with non erosive subtype of hand osteoarthritis and 20 patients with erosive subtype of hand osteoarthritis. A clinical evaluation of hand osteoarthritis will be performed. Blood sample for proteomic analysis will be taken. Hand MRI and Bone Mineral Analyser will be performed.
Interventions
PROCEDUREBiological sampling
Biological sampling to identify by label-free proteomic analysis of a combination of serum biomarkers in patients with Erosive and non erosive hand Osteoarthritis
DEVICERadiographic evaluation
Radiographic assessments using Bone Mineral Analyser and Hand MRI will be done in patients with Erosive and non erosive hand Osteoarthritis
Sponsors
University Hospital, Rouen
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* Female gender * Less than 70 years old * Diagnosis of hand osteoarthritis according to ACR criteria ACR after exclusion of thumb base osteoarthritis: 1. Hand pain, aching or stiffness most of the days during the preceding month 2. Hard tissue enlargement of at least two of 8 selected joints \* 3. Hard tissue enlargement of at least two distal interphalangeal joint 4. Swelling of fewer than three metacarpophalangeal joint 5. Deformity of at least one of 10 selected joints \* Patients have to fulfil criteria 1, 2 AND 3 + 4 OR 5 \* the 8 selected joints are the second and third distal interphalangeal joint and the second and third proximal interphalangeal of both hands Then confirm by experts' committee * Exclusively symptomatic treatment * For women of child-bearing age, use of an effective contraceptive method * French spoken and read
Exclusion criteria
* Male gender * More than 70 years old * Hemochromatosis * Inflammatory arthritis * Cristal induced arthritis * Active diseases such as infection or cancer * Use of DMARDs * Pregnant or breast-feeding woman
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Quantification by label-free proteomic analysis of the serum of patients affected by hand osteoarthritis | day 1 | Assessments done using biological sampling |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Number of Erosion in patients affected by hand osteoarthritis | Day 1 | Number of Erosion in patients affected by hand osteoarthritis is evaluated using Bone Mineral Analyser |
Countries
France
Outcome results
None listed