Adenocarcinoma, Cancer of Lung, Cancer of the Lung, Carcinoma, Non-small-cell Lung, Lung Cancer, Lung Neoplasms, Neoplasms, Lung, Neoplasms, Pulmonary, Pulmonary Cancer, Pulmonary Neoplasms, Squamous Cell Carcinoma
Conditions
Brief summary
The purpose of this study is to isolate and measure circulating tumor cells in the blood stream to advance detection of cancer and treatment monitoring. In this study, the investigators will utilize the novel technology for circulating tumor cell detection in order to evaluate their presence in patients with lung cancer.
Detailed description
The plan is to collect both blood and tumor samples from the patient's lung cancer in order to validate this technology in detecting circulating tumor cells. The investigators will also obtain a postoperative blood sample to see if there is a decrease in the overall circulating tumor cell measurement once the tumor has been surgically removed.
Interventions
None listed
Sponsors
Clearbridge Biomedics
Mayo Clinic
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Stage IB and above non-small cell lung cancer or metastatic lung cancer * Age \>18 years old * Willing and able to consent to study * No prior history of neoadjuvant therapy.
Exclusion criteria
* Age \<18 years old * Unable to provide consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number and types of mutations in the primary tumor. | Within 1 year |
| Number and type of mutations detectable in the matched circulating tumor cell samples. | Within 1 year |
Secondary
| Measure | Time frame |
|---|---|
| Concordance of mutations detected by either method. | Within 1 year |
Countries
United States
Outcome results
None listed