Idiopathic Epilepsy
Conditions
Keywords
Vitamin C, convulsions status, EEG, children
Brief summary
There are no solid treatment guidelines for idiopathic intractable epilepsy in children. The investigators propose that vitamin C being an antioxidant will improve seizure frequency and EEG in children with idiopathic intractable epilepsy.
Detailed description
Is vitamin C; being an antioxidant based on the hypothesis of oxidative stress as a provocation factor for idiopathic epilepsy low in those with idiopathic epilepsy, and is it lower in those with refractory than those with newly diagnosed? Will vitamin C supplementation for 1 month be efficient to raise the vitamin C level and will it improve seizures and EEG findings in those with idiopathic epilepsy?
Interventions
DIETARY_SUPPLEMENTVitamin C
those who are 2-3 years will receive 400 mg/day, 4-8 years will receive 500 mg/day, those who are 9-13 years will receive 1000 mg/day, and from 14-16 years will receive 1500 mg/day
Sponsors
Ain Shams University
Study design
Allocation
RANDOMIZED
Intervention model
FACTORIAL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
2 Years to 16 Years
Healthy volunteers
No
Inclusion criteria
* Normal neuroimaging
Exclusion criteria
* Developmental delay. * Suspected metabolic problems.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Seizure severity and frequency, EEG findings | up to 30 days | Seizure severity based on the Chalfont seizre severity scale and daily seizure frequency will be measured before and 30 days after vitamin C supplementation in children with intractable idiopathic epilepsy |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| vitamin C level in children with epilepsy | 6 months | children with epilepsy will be recruited over a period of 6 months and we will measure vitamin C level in their blood |
Countries
Egypt
Outcome results
None listed